CARMA1 Controls Th2 Cell-Specific Cytokine Expression through Regulating JunB and GATA3 Transcription Factors
نویسندگان
چکیده
منابع مشابه
CARMA1 controls Th2 cell-specific cytokine expression through regulating JunB and GATA3 transcription factors.
The scaffold protein CARMA1 is required for the TCR-induced lymphocyte activation. In this study, we show that CARMA1 also plays an essential role in T cell differentiation. We have found that the adoptive transfer of bone marrow cells expressing constitutively active CARMA1 results in lung inflammation, eosinophilia, and elevated levels of IL-4, IL-5, and IL-10 in recipient mice. In contrast, ...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2012
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.1102943